I received my Ph.D. in molecular cell biology from Erasmus University Rotterdam, where I studied the process of hematopoiesis during mammalian embryonic development, using a model system of mouse embryonic stem cell differentiation. As a post-doctoral researcher I worked on investigating the role of the bone marrow stromal microenvironment in leukemic evolution and bone regeneration as well as the molecular mechanisms that regulate the role of mesenchyme derived cells in these two distinct processes. I joined Canterbury Christ Church University in 2014 and I am currently a Senior Lecturer in Biochemistry.
My research is focused on stem cell biology and differentiation. My main interests include the interrogation of genes and signalling pathways that govern the process of embryonic stem cell differentiation towards hematopoiesis and neural development
Teaching and subject expertise
Currently I am teaching on the following modules:
Core Science (module director)
Molecular Biology (module director)
Publications and research outputs
Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.
Zambetti NA, Ping Z, Chen S, Kenswil KJ, Mylona MA, Sanders MA, Hoogenboezem RM, Bindels EM, Adisty MN, Van Strien PM, van der Leije CS, Westers TM, Cremers EM, Milanese C, Mastroberardino PG, van Leewen JP, van der Eeerden BC, Touw IP, Kuijpers TW, Kanaar R, van de Loosdrecht AA, Vogl T, Raaijmakers MH. Cell Stem Cell. 2016 Sep 10
Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS
reveals tissue-context dependent activation of inflammatory programs.
Chen S, Zambetti NA, Bindels EM, Kenswill K, Mylona AM, Adisty NM, Hoogenboezem RM, Sanders MA, Cremers EM, Westers TM, Jansen JH, van de Loosdrecht AA, Raaijmakers MH. Leukemia. 2016 Jun 3
The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct
Differentiation of Multipotent Cardiac Progenitors.
Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. Cell Stem Cell. 2015 Sep 3; 17(3): 287-299
Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis.
Mylona A, Andrieu-Soler C, Thongjuea S, Martella A, Soler E, Jorna R, Hou J, Kockx C, van Ijcken W, Lenhard B, Grosveld F. Blood. 2013 Apr 11; 121(15):2902-13
Genomic structure and cloning of two transcript isoforms of human Sp8.
Maria-athina Milona, Julie E Gough and Alasdair J Edgar. BMC Genomics, 5:86, Nov 2004
Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells.
Maria-athina Milona, Julie E Gough and Alasdair J Edgar. BMC Genomics, 4:43, Nov 2003