PhD Student Profile

Tyler Howell-Bray

Tyler Howell-Bray

PhD Student

School: School of Human and Life Sciences

Campus: Canterbury

Project title

‘Understanding the metabolic consequences of protein mis-folding.’ 

Profile summary

I joined CCCU in 2010 as a student on the Science foundation programme. Between my second and third year I worked as a volunteer for one of the leading stem cell research charities, gaining a valuable understanding of the impact of medical science on human life. Inspired by I undertook a final year dissertation project on prion research, alongside Dr Lee Byrne. This granted me the opportunity to gain key protein, molecular and biochemistry skills. In September 2014 I joined the CCCU staff team as a University Instructor. My roles include instructing on a variety of courses, mainly practical, engaging students and passing on the knowledge she gained as a student here. In addition I am conducting research, working closely with her supervisors, Dr Lee Byrne and Dr Simon Harvey, on understanding the metabolic consequences of protein mis-folding using a variety of analytical technology (NMR and MS). This research aims to better understand the interactions of these troublesome promiscuous proteins on normal cellular functioning, with plans to eliminate these effects via genetic manipulation. Working mainly with the model organism Saccharomyces cerevisiae (brewer’s yeast), this research bridges a gap between two fields, metabolomics and prion/amyloid biology. With the overall aim to increase fundamental understanding about the toxic effect of prions and other mis-folded proteins, such research is  crucial in our efforts to understand and control crippling age onset disease such as Alzheimer’s, Parkinson’s and Huntington’s. ​


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Last edited: 05/12/2017 01:03:00